C-reactive Protein Levels, Waist Circumference, and Pregnancy Outcomes in Overweight and Class 1 Obese Women
ACOG ePoster. Rives T. Apr 27, 2018; 211706; 37I
Ted Rives
Ted Rives
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Introduction: To determine effects of adipose distribution and baseline CRP in 1st trimester on development of pregnancy-related conditions of GDM, GHTN, and preeclampsia in pregnancies with normal BMI compared to BMI 25-35 stratified by waist circumference (WC).

Methods: Prospective study including 3 cohorts: Group I Controls (BMI 18.5-25); Group II Subcutaneous Adipositiy (BMI 25-35, WC 35 in). Patients were eligible if enrollment 30 (p=0.01), noting intake mean CRP (GI 1.7, GII 1.4, GIII 4.7). CRP3.0 in 1st trimester increased risk for GHTN/preeclampsia (OR 3.35).

Conclusion/Implications: Visceral adiposity increases systemic inflammation defined by elevated intake CRP and risk for GDM. Increased incidence of complications in obese mothers may be rooted in inflammatory insults to early placental development. Future studies may assess CRP utility as a risk stratification tool.
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