Does Pregnancy Weight Gain Increase the Risk of Metformin Failure in the Treatment of Gestational Diabetes?
ACOG ePoster. Persad M. Apr 27, 2018; 211685; 35D
Malini Persad
Malini Persad
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Abstract
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Introduction: To determine if maternal weight gain is associated with a higher risk of metformin failure in women with gestational diabetes (GDM).

Methods: A retrospective cohort study of women with GDM was conducted from 2013-2016. Included in the study were women with GDM started on metformin after a failed trial of diet therapy. Excluded from the study were women with pre-existing diabetes mellitus. Women were categorized as having adequate glycemic control on metformin (metformin success) or requiring the addition of or transition to an insulin regimen (metformin failure). Metformin failure was defined as the inability to obtain glycemic control despite utilization of the maximum metformin dosage, or provider discretion. Maternal demographics and weight parameters were collected from the medical records and compared between the 2 groups. Parametric and nonparametric statistical analyses
were performed with a p value of
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