Racial Disparities in Low PAPP-A Levels and Pregnancy Outcomes
ACOG ePoster. Shand M. Apr 27, 2018; 211641
Muhammed Shand
Muhammed Shand
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Abstract
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Introduction: Pregnancy-associated plasma protein A(PAPP-A) is associated with adverse pregnancy outcomes: preterm birth, growth restriction, stillbirth and preeclampsia. The association of low PAPP-A and pregnancy outcomes based on race is unknown. The objective of this study was to determine if low PAPP-A is associated with labor dysfunction in different racial populations.

Methods: Retrospective study of pregnant women with PAPP-A ≤5%ile between 7/2013-7/2016. Outcomes of non-Hispanic white (NHW) womenwere compared to non-Hispanic black (NHB) women. Primary outcome: cesarean delivery (CD) rate. Secondary outcomes: indication for CD, perinatal outcomes. Exclusion: women with fetuses with known or suspected aneuploidy.

Results: 114 women were included; 69 NHW women and 45 NHB women. Demographical differences included maternal age at delivery (35.0 ± 4.1 weeks in the NHW group vs.30.5 ± 5.6 in the NHB group, p
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