Can the 2-hour Glucose Tolerance Test (GTT) Values Predict Metformin Failure in Women with Gestational Diabetes?
ACOG ePoster. Persad M. Apr 27, 2018; 211545
Malini Persad
Malini Persad
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Abstract
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Introduction: To determine if the GTT values have utility in predicting metformin failure in women with gestational diabetes (GDM).

Methods: A retrospective cohort study of women with GDM was conducted from 2013-2016. Included in the study were women with GDM started on metformin after a failed trial of diet therapy. Excluded from the study were women with pre-existing DM, or were started on glyburide or insulin therapy initially. Women were categorized as having adequate glycemic control on metformin (metformin success) or requiring the addition of or transition to an insulin regimen (metformin failure). Maternal demographics and GTT values were collected. The sensitivity and the specificity of the GTT values as a screening test for metformin failure were analyzed and the corresponding ROC curves were plotted to assess the performance of the test. Parametric and nonparametric statistical analyses were performed with a p value of
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