The Safety of RT for the Management of FIGO Stages IA-IIA Cervical Cancer : An Updated Meta-Analysis with TSA
ACOG ePoster. Feng Y. Apr 27, 2018; 211493; 27Q
Ying Feng
Ying Feng
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Introduction: This study aimed to evaluate the safety of RT for the management of stages IA-IIA cervical cancer and to initiate new investigations based on the findings of previous studies published in the literature.

Methods: The PubMed, EMBASE, Web of Science and Cochrane databases were searched to collect correlational, prospective, CCTs published in English from 1984 to April 2017. A meta-analysis and TSA were performed to evaluate the oncologic and reproductive outcomes of patients treated with RT.

Results: A total of 5 prospective CCTs with 818 patients were ultimately pooled in this analysis. The recurrence and death rates were similar between RT and RH. Patients with a tumor 2-4 cm in diameter were more likely to be treated with RH than RT, which might be a potential contributor to the higher ratio of postoperative adjuvant chemotherapy in this patient group. Additionally, RH was associated with a significantly higher risk of intraoperative blood transfusion. The TSA indicated that the cumulative number of patients failed to fulfill the required sample size. Promising negative section margins were obtained through RAT, but patients with a tumor 2-4 cm in diameter were more likely to be treated with RH. Moreover, the clinical outcomes of RAT were slightly more favorable than those of RVT.

Conclusion/Implications: RVT is safe and feasible for early-stage cervical cancer patients with a tumor less than 2 cm in diameter. RAT could be cautiously recommended as an alternative for patients with a tumor 2-4 cm in diameter. However, further CCTs are warranted to validate these results.

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